If you have sinus issues that result in congestion, you might want to consider a full face mask vs one with just nasal pillows.
If you are eligible for TSA PreCheck for your flight, you don't need to take the machine out of the carry bag. Even if you aren't eligible, ask if you need to take it out and sometimes they'll let you keep it in the bag.
If you take soap or vinegar, remember the container has to be less than 3 fl oz.