I'm hoping that you've found some information since your original post... I'm new to my CPAP (AirSense 11). AHI was 70 (!!), with a mix of (mostly) OSA and CSA, down to less than 2. I've been using it since 2/14 and, other than obesity, have no chronic issues and take no medications. I've only ever experienced LE edema sporadically during long distance car travel (10-12 hours). Currently, I have my settings at: auto ramp at 4 and it runs up to 11 overnight. I use nasal pillows with zero leaks and have had no adverse issues until this started over the last week. This was the only information I've found regarding increased LE edema with CPAP use!
