Hi Rayrae - I have been reading your posts. I too am having a lot of fatigue after starting with APAP and can't figure it out. I no longer have bad restless leg syndrome so that isn't an issue for me. BUT I wanted to give you some info on that. You may want to look into a site called parathyroid.com and look at symptoms for hyperparathyroid. The tingling in hands and feet could be due to calcium issues. Also, I had practically all the symptoms for more than 15 yrs before I found a doctor who figured out my issue - hyperparathyroid with a parathyroid gland that had turned into an adenoma (benign tumor) it wasn't in my neck like it was supposed to be but under my breastbone so it couldn't be palpated. I was also craving calcium all the time and was taking high doses of calcium which kept my bloodwork from showing the issue. Once I had the bad parathyroid gland taken out I haven't had restless leg syndrome anymore. ALSO, you may want to look into thyroid issues since fatigue and restless leg syndrome can be from that too. Good luck in finding the answer!