I have since gotten rid of the ResMed AirMini and replaced it with Transcend 365. It uses distilled water like my home unit and I have not experienced any problems. That being the case, the HME has be the issue as it was the only difference and problem among now three machines.
I too am having allergic type reactions (teary puffy eyes and watery nasal drip) with AirMini after I use it for more than two consecutive nights. My supplier and Resmed say they have never had this problem occur before. I don't believe them as you have had similar problems. As best I can tell, it is related to HumidX HME cartridge. I have no such problems with my Resmed home unit using distilled water. I have paid to have the CPAP machine replaced, used cleaned tubes, new nasal pad, new HumidX and replaced the air intake filter. Still having the same problem beginning on the third night of consecutive use. Any solutions found other than quit using the product?