On the mask leakage issue, she has tried 3 of the better and more popular masks. There are a couple of newer ones of the minimal contact style. My thoughts are that the higher the pressure the more force the mask puts on the face and on the straps. If the mask size is minimized then the area this pressure acts on is reduced, and conceivably the force in the straps is reduced.
I believe the Phillips DreamWear mask was introduced early this year. This mask frame can use a minimal full face, a nasal, and a nasal pillow type insert. The full face version might work better than the three she has tried. Here is some more information on it.
DreamWear Minimal Contact Full Face Mask
More recently ResMed has come out with one they claim is better, and in a test was preferred two to one over the DreamWear mask.
ResMed AirFit F30 Minimal Contact Full Face Mask
But, really until she tries the mask, you don't know if it will work. Some people have had success with using a mask liner where the mask fits to the face.
Mask Liners
With respect to the high AHI about all you can do is work with the provider. You could ask whether it is central apnea that is driving it up or obstructive apnea. If it is obstructive then she probably needs more EPAP pressure and the machine may already be at the maximum. If it is central apnea then the pressure support may need to be adjusted. There is a free software program called SleepyHead which will download the data from the SD card in the machine so you can view it. If you want more info on it just ask.
Here is a link to a document from ResMed which includes some basic details on what the machine is supposed to do and the basic setup paramaters for ASV mode, and for ASV Auto. See pages 27 through 31. SleepyHead will allow you to see the same level of detail as is shown on page 31 for flow rate, pressure and minute ventilation. You should be able to see if the machine is working as it is designed.
Sleep Lab Titration Guide