Hello, I am a dentist working in dental sleep medicine. First of all, which oral appliance did you try? The Tap 3 line(TAP3, DreamTap) has been acknowledged within the dental sleep medicine as significantly more effective for severe OSA than other alternatives. If you haven't tried a TAP, you haven't given it your best shot. Secondly, there would definitely be hope for you with a combination device called the Tap-Pap CS. It incorporates a Tap OSA appliance into a nasal pillow mask and has a patented intraoral mouth shield that eliminates leakage through the mouth from mouth breathing. It is highly effective(better than CPAP or an oral appliance alone) and studies of people who have been CPAP intolerant, but for whom the OAs were ineffective, that 70 percent of those patients COULD successfully manage with the Tap-Pap CS. Those odds are pretty good, don't you think? Arthur B. Luisi, Jr.,D.M.D.